Ex parte HOUGHTEN et al. - Page 5




                  Appeal No. 1996-3434                                                                                       
                  Application No. 08/063,279                                                                                 




              libraries are not claimed here.@  The examiner=s statement of the rejection addresses                          

              the side chains by stating:                                                                                    
                             It would have also been obvious that such libraries would                                       
                             have the carboxamide groups replaced by aminomethyl                                             
                             groups, carboxyl groups replaced by hydroxymethyl, and                                          
                             guanidino groups replaced by amino groups, because one                                          
                             of ordinary skill would have also expected these groups to                                      
                             be reduced by the reductants and procedures which are                                           
                             well known and routine in the art, as one would not be                                          
                             concerned with trying to maintain the structure and activity                                    
                             of a parent peptide.                                                                            
              See, Answer, page 6.                                                                                           
                      We have no doubt that the prior art could be modified in a manner consistent                           
              with appellants’ specification and claims.  That the prior art could be so modified,                           
              however, would not have made the modification obvious unless the prior art suggested                           
              the desirability of the modification.  In re Gordon, 733 F.2d 900, 902, 221 USPQ 1125,                         
              1127 (Fed. Cir. 1984).  What is lacking from the examiner=s treatment of the claims on                         

              appeal is a reason, suggestion or motivation, stemming from the prior art, which would                         
              have led a person having ordinary skill to the claimed invention wherein Athe                                  

              carboxamide groups of said reduced amino acid side chains are replaced by                                      
              aminomethyl groups, carboxyl groups of said reduced amino acid side chains are                                 
              replaced by hydroxymethyl groups, and quanidino groups of said reduced amino acid                              

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