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89, 90, 92 and 93, all the claims remaining in the
application. Claims 7 and 81 are representative:
7. A mammalian cell consisting essentially of a cell
transfected by a first expression vector, said transfected
cell being capable of producing a biologically active
heterodimeric protein having first and second subunits, said
selected protein being selected from the group consisting of
luteinizing hormone (LH), follicle stimulating hormone (FSH),
chorionic gonadotropin (CG) and thyroid stimulating hormone
(TSH), each of said subunits of said protein being encoded by
said first expression vector under the control of a separate
promoter, or progeny of said transfected cell containing the
promoters and DNA sequences for said subunits imparted by said
vector.
81. A mammalian cell consisting essentially of a cell
transfected by a first expression vector and a distinct second
expression vector, said transfected cell being capable of
producing a biologically active heterodimeric protein having
first and second subunits, said protein being selected from
the group consisting of luteinizing hormone (LH), follicle
stimulating hormone (FSH), chorionic gonadotropin (CG) and
thyroid stimulating hormone (TSH), the first subunit of said
protein being encoded by said first expression vector and the
second subunit of said protein being encoded by said second
expression vector, or progeny of said transfected cell
containing the promoters and DNA sequences for said subunits
imparted by said vectors.
The prior art discussed by appellants includes:
Shome et al. (Shome), “The Primary Structure of Bovine
Thyrotropin,” 246 The Journal of Biological Chemistry, No. 4,
pp. 833-849 (1971).
Maghuin-Rogister et al. (Maghuin-Rogister), “Porcine
Thyrotropin. The Amino-Acid Sequence of the " and $ Subunits,”
61 Eur. J. Biochem., pp. 157-163 (1976).
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