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Sairam et al. (Sairam), “Human Pituitary Thyrotropin. The
Primary Structure of the " and $ Subunits,” 55 Can. J.
Biochem., pp. 755-760 (1977).
Gurr et al. (Gurr), “Cloning of cDNA Encoding the pre-$
Subunit of Mouse Thyrotropin,” 80 Proc. Natl. Acad. Sci. USA,
pp. 2122-2126 (April, 1983).
Vamvakopoulos et al. (Vamvakopoulos), “Synthesis, Cloning, and
Identification of DNA Sequences Complementary to mRNAs for "
and $ Subunits of Thyrotropin,” 77 Proc. Natl. Acad. Sci. USA,
No. 6, pp. 3149-3153 (1980).
Pierce et al. (Pierce), “Glycoprotein Hormones: Structure and
Function,”
50 Ann. Rev. Biochem., pp. 465-495 (1981).
The examiner has not relied on prior art in rejecting the
claims on appeal. Rather, the claims stand rejected under 35
U.S.C. § 112, first paragraph, as based on a non-enabling
disclosure. We reverse. In addition, we raise an issue for
the examiner and appellants to consider upon return of the
application.
DISCUSSION
Background
Luteinizing hormone (LH), follicle stimulating hormone
(FSH), chorionic gonadotropin (CG), and thyroid stimulating
hormone (TSH) are heterodimeric proteins with identical alpha
subunits and similar, but distinct, beta subunits. Claims 7,
13, 15 through 19, 28, 36, 81, 82 and 93 are drawn to
3
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