Ex parte CHU et al. - Page 4




          Appeal No. 1997-0204                                                        
          Application No. 08/400,786                                                  


               We have carefully reviewed the specification, claims and               
          applied prior art, including all of the arguments advanced by               
          both the examiner and appellants in support of their                        
          respective positions.  This review leads us to conclude that                
          the examiner’s § 103 rejections are not well founded.  We                   
          reverse each of the examiner’s § 103 rejections for                         
          essentially those reasons set forth in the Brief.  We add the               
          following primarily for emphasis and completeness.                          
               The claimed subject matter is directed to a device for                 
          detecting an analyte in a biological fluid.  The device                     
          includes “a separation matrix containing an agglutinating                   
          agent and between 70 and 150 millimolar of 4-(2-hydroxyethyl)-              
          1-piperazine-ethanesulfonic acid (HEPES)” and means for                     
          detecting the analyte.  See claim 28.   The presence of the                 
          HEPES buffer in the separation matrix is said to provide a                  
          faster endpoint detection. Id.                                              
               The examiner states that both Chu ‘485 and ‘843 disclose               
          essentially the device recited in claims 28, except that they               
          fail to include between 70 and 150 millimolar of HEPES in                   
          their separation matrix.  See Answer, pages 4, 5, 7, 8 and 9.               
          The examiner then relies on Wilk to demonstrate that it would               
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