Appeal No. 1997-0875
Application No. 07/998,128
induction of plasminogen activators; (b) loss of anchorange dependence; and (c)
mitogenesis (p. 2, ll. 57-62).
Sundsmo discloses a wound healing composition comprising an aqueous mixture
of fibrillar collagen, heparin and undegranulated platelets or platelet releasate (abstract; c.
2, ll. 37-47), which "promotes re-epitheliazation, fibroplasia, granulation tissue deposition,
vascularization and new host collagen synthesis at wound sites" (c. 2, ll. 21-24).
Senior discloses that each of three proteins obtained from platelet alpha granules,
i.e., platelet factor 4 (PF4), platelet-derived growth factor (PDGF) and ß-thromboglobulin
(BTG), is strongly chemotactic for fibroblasts (abstract).
Rose discloses a fibrin adhesive prepared as a concentrate from single donor fresh
frozen plasma (FFP) (abstract) and states that "the use of single donor FFP entails no
greater risk of transmission of Hepatitis B, Acquired Immune Deficiency Syndrome, and
other serologically transmitted illness than transfusion of a unit of fresh frozen plasma" (p.
12, ll. 31-34) and, thus, presents a decreased risk of blood born infection vis-a-vis fibrin
concentrate from pooled donors (p. 12, l. 35 - p. 13, l. 3).
According to the examiner,
[w]hile none of the references individually disclose the combination of
all of the components of the claimed composition, it would have been
obvious to one of ordinary skill in the art to combine the individual
components, each of which is taught by the prior art to be useful for the same
purpose, i.e., wound healing and tissue repair, in order to form a resultant
composition that is to be used for the exact same purpose. The idea of
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