Ex parte BECHER et al. - Page 4




              Appeal No. 1997-2336                                                                                          
              Application No. 08/256,065                                                                                    
              Castleman, “The 2-cent Miracle Medicine that Fights Heart Disease, Cancer, and more,"                         
              Family Circle, Vol. 108, No. 3, p. 20 (Feb. 21, 1995)                                                         
              Nelson, “Aspirin Prevention Update: New Data on Lung and Colon Cancers,” Journal of the                       
              National Cancer Institute, Vol. 87, No. 8, pp. 567-569 (April 19, 1995)                                       
              Giovannucci et al. (Giovannucci), “Aspirin and the Risk of Colorectal Cancer in Women,”                       
              The New England Journal of Medicine,” Vol. 333, No. 10, pp. 609-614 (Sept. 7, 1995)                           
              Harris, et al. (Harris), "Nonsteroidal Antiinflammatory Drugs and Breast Cancer,”                             
              Epidemiology, Vol. 7, No. 2, pp. 203-205 (March 1996)                                                         
              Munson et al. (Munson), Prevention, Vol. 48, No. 7, page 19-20 (July 1996)                                    
                     The following reference is relied upon by this merits panel:                                           
              Kissel                               5,861,170                           Jan. 19, 1999                        
                                                  Ground of Rejection                                                       

                     Claims 27-36 stand rejected under 35 U.S.C. § 112, first paragraph, as being non-                      
              enabled by the specification.  For the reasons discussed below, we affirm the rejection of                    
              claim 27-35, vacate the rejection of claim 36 and enter a new ground of rejection of claims                   
              27-29 under the provisions of 37 CFR § 1.196(b).                                                              
                                                      Background                                                            

                     Appellants describe the invention at page 5 of the specification as being directed                     
              to a transdermal application system for the administration of acetylsalicylic acid or its                     
              pharmaceutical salts for antithrombotic therapy and prophylaxis against cancer.  The                          
              system is described as avoiding the disadvantages associated with oral application and                        
              allows for target-specific dosages of the unchanged active substance.                                         




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