Ex parte PANETTIERI et al. - Page 4




              Appeal No. 1997-2756                                                                                        
              Application 08/242,728                                                                                      


              of Murray is histamine. (Answer, page 5).  The examiner has not established, on this                        
              record, that histamine is an antithrombin agent.  That the reference may suggest or                         
              describe the metabolic pathway associated with the condition being treated does not,                        
              standing alone, suggest the specific treatments presently claimed.  Thus, Murray fails to                   
              anticipate the rejected claims.  Therefore, the rejection of claims 3 and 6 under 35 U.S.C.                 
              § 102 is reversed.                                                                                          
                                         The rejection under 35 U.S.C. § 103                                              
                     In rejecting the claims under 35 U.S.C. § 103 the examiner notes that Roth, at page                  
              1218, teaches the use of nedocromil sodium to treat asthma. (Answer, page 3).  The                          
              examiner, additionally, notes that Roth teaches, at page 1222, column 1, first paragraph                    
              under DISCUSSION and page 1224, column 1, first full paragraph,  that nedocromil                            
              sodium blocks or interferes with thrombin activity.  (Answer to the Reply Brief, page 1).                   
              That nedocromil sodium interferes with thrombin activity is acknowledged at page 2, lines                   
              5-9 of the Specification.                                                                                   
              Claim 6:                                                                                                    

                     As to claim 6, we would agree with the examiner's determination that the claim  is                   
              unpatentable as being at least obvious over Roth.  It would appear that the examiner has                    
              presented the rejection in terms of 35 U.S.C. § 103 in view of the focus on mechanism of                    
              action or the pharmacological pathway, described by appellants, on                                          


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