Ex parte MANZ et al. - Page 11




         Appeal No. 1997-3328                                                    
         Application No. 08/226,605                                              


         (specification, page 9). The preferred embodiment being                 
         subsequently described with respect to Fig. 4.                          
         The advantages described include "the leakage or diffusion of           
         sample components is considerably decreased ... the noise of            
         the detected signal is reduced ... [and] the sensitivity of             
         the analytic system, that is the limit of detection, is                 
         increased" (specification, page 9).                                     
              The examiner's rejection of claim 20 is based on                   
         Verheggen's description of a basic electrophoretic device and           
         Harrison's teaching of electrokinetically introducing the               
         sample "by applying a voltage (pt electrodes) between the               
         separation channel and supply channel" (examiner's office               
         action mailed May 16, 1995, Paper No. 3, page 5).5   The                
         examiner also notes "Harrison also teaches that manipulation            
         of channel geometry is possible to control where the applied            
         potential drops.  Kindly refer to Fig. 1; 1928, Results and             
         Discussion, the two paragraphs" and concludes that "[i]t would          
         have been obvious to one of ordinary skill in the art to                


                                                                                
         5 The final rejection (Paper No. 6) rejects then claim 12 (replaced in Paper
         No. 7 in favor of claim 20) by reference to "the office action mailed May 16,
         1995" for an explanation of the rejection.                              
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