Ex parte ITO et al. - Page 10




          Appeal No. 1998-2836                                                        
          Application No. 08/453,211                                                  


          disclosed in Ito.  In our view, the substitution of calcium                 
          phosphate derived from powdered bone for HAp in the                         
          composition disclosed in Ito would have been obvious to the                 
          artisan and the artisan would have had a reasonable                         
          expectation of success in doing so based on Oonishi's specific              
          disclosure that calcium phosphate derived from powdered bone                
          and HAp were known equivalents in the art.  See, Oonishi, col.              
          4, ll. 38-43.                                                               
               As should be apparent from our understanding of the                    
          meaning of the language “animal bone powder,” supra, it is our              
          opinion that the language “a bone substitute material                       
          comprising animal bone powder” reads on the material taught by              
          the combined teachings of Ito and Oonishi because calcium                   
          phosphate derived from powdered bone is “animal bone powder”                
          as that language is construed in view of the underlying                     
          specification.                                                              
               Claim 3, dependent from claims 1, 22 and 23, requires                  
          both animal bone powder and chemically synthesized particulate              
          HAp.  The appellants argue that the applied prior art fails to              
          suggest a bone substitute material containing both animal bone              
          powder and chemically synthesized particulate HAp.  See main                
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