Ex parte ITO et al. - Page 15




                 Appeal No. 1998-2836                                                                                                                   
                 Application No. 08/453,211                                                                                                             


                 which teaches a hardenable composition containing chitosan                                                                             
                 sol, commercially available HAp  and zinc oxide and/or  8                                                                              
                 magnesium oxide powder.  Specifically, Ito discloses an                                                                                
                 Example No. 5 comprising 1.0 g chitosan solution, .46 g HAp,                                                                           
                 .03 g zinc oxide, and .01 g calcium oxide having a hardening                                                                           
                 time of 2 min and a compressive strength of 21.6 kg/cm .  The                                    2                                     
                 37 CFR § 1.132 declaration states that the reported                                                                                    
                 experiments were performed on samples manufactured as                                                                                  
                 described on pages 14 and 15 of the appellants’ specification.                                                                         
                 Page 14 of the specification describes a sample containing                                                                             
                 bovine bone powder and HAp.  A sample containing “a small                                                                              
                 amount of hydroxyapatite without any bovine bone powder” is                                                                            
                 described on page 15.  The specification does not identify                                                                             
                 what constitutes “a small amount of hydroxyapatite” or whether                                                                         
                 all types of commercially available HAp were tested.  The                                                                              
                 samples containing apatite, rather than HAp, are even more                                                                             
                 unlike the composition disclosed in Ito.  Thus, the evidence                                                                           



                          8Based on Oonishi’s reference to “synthetic HAp,” we                                                                          
                 understand that “commercially available hydroxyapatite” also                                                                           
                 includes natural HAp, i.e., HAp derived from a living body or                                                                          
                 from powdered bone.                                                                                                                    
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