Appeal No. 1998-2836 Application No. 08/453,211 calcium phosphate derived from powdered bone or animal bone powder is present as a residual component in the composition disclosed by Oonishi does not teach away from the substitution of calcium phosphate derived from powdered bone for HAp in the composition disclosed by Ito, since Oonishi is not relied on for its teaching of the proportion of HAp in a hardenable composition but only for its teaching of the interchangeability of calcium phosphate derived from powdered bone and synthetic HAp in a hardenable composition of the type disclosed by Ito. The appellants also argue (main brief, pp. 11-12) that even if Oonishi suggests the inclusion of powdered bone and HAp in the same group of substances useful for the residual component in Oonishi’s composition, such is not a teaching that HAp and animal bone powder are “equivalent” in the Ito composition. This argument is not well taken because, in our opinion, the evidence of record establishes that an artisan would have understood that calcium phosphate derived from powdered bone is mainly HAp. We note every reference relies to some extent on knowledge of persons skilled in the art to complement that which is disclosed therein. See In re Bode, 18Page: Previous 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 NextLast modified: November 3, 2007