Interference 102,413 Page 3
Pitha v. Muller
The subject matter of this interference involves the
production of a stabilized amorphous complex of a drug and a
mixture of cyclodextrin derivatives. Cyclodextrins are cyclic
oligosaccharides built up from six ("), seven ($) or eight (()
glucopyranose units. The non-selective alkylation of1
cyclodextrin forms a cyclodextrin derivative. The stabilized 2
complexes are said to be useful for the formation of
pharmaceuticals which have improved drug dissolution
properties and absorption by the body.3
Pitha claims 1-28 and Muller claims 1-11 and 22-36
correspond to count 3. Count 3, the sole count in the
interference follows:
Count 3
A method of producing a stabilized amorphous complex
of a drug and a mixture of cyclodextrins which
comprises the steps of:
1. Dissolving an intrinsically amorphous mixture
of cyclodextrin derivatives which are water
soluble and capable of forming inclusion
complexes with drugs in water; and
2. Solubilizing lipophilic drugs into the
aqueous media to form a solution and form a
solubilized drug/cyclodextrin derivative complex;
or
1J. Szejtli “Cyclodextrins and Their Inclusion
Complexes,” Akademiai Kiado, Budapest Hungary 1982, p. 13.
2Pitha ‘064, column 1 lines 11-14.
3Pitha ‘064, column 1 lines 26-36.
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Last modified: November 3, 2007