Ex parte BUIRGE et al. - Page 6




          Appeal No. 2000-0673                                                        
          Application No. 08/960,276                                                  


               Claims 56 and 58 read:                                                 
          56. The method of claim 55 wherein the stent functions as a                 
          cathode in an anode/cathode pair and is immersed in an aqueous              
          electrolyte solution including collagen and an electrical                   
          potential is established between the anode and cathode                      
          adequate to sustain electrodeposition of the collagen from the              
          solution onto the metal surface of the stent.                               
          58. The method of claim 56 wherein the potential is about 3                 
          volts.                                                                      
               In discussing the voltage to be applied between the                    
          electrodes (the cathode being the item to be coated), Vieth                 
          states at col. 5, line 65 to col. 6, line 3:                                
               Voltage and current requirements are dependent upon                    
               the dimensional parameters of a given system, such                     
               as the area of the support to be coated, the                           
               distance between electrodes, the temperature, and                      
               the concentration of materials and electrolytes in                     
               the aqueous mixture.  Generally, it is preferable to                   
               use a relatively low voltage supply, such as from                      
               about 10 to 100 volts.  The actual current                             
               requirements are quite small, generally from 1 to 10                   
               amperes.  Working at low voltages avoids an                            
               undesirable increase in temperature, which may                         
               denature the enzyme or its carrier, and also tends                     
               to favor electrophoresis over electrolysis.                            
               Voltages for a given application can be readily                        
               determined by simple trial and error.                                  
          While the about 3 volts recited in claim 58 is lower than the               
          voltage range disclosed by Vieth, supra, as generally                       
          preferable, we consider that it would have been obvious to use              
          that voltage when electrodepositing collagen onto the stent of              
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