Appeal No. 2001-1412 Paper No. 29
Application No. 08/629,177 Page 2
Rutner et al. (Rutner) 4,256,725 Mar. 17, 1981
Freundlich et al. (Freundlich) 4,857,454 Aug. 15, 1989
Diamandis et al. (Diamandis) 5,089,423 Feb. 18, 1992
Deeg et al. (Deeg) 5,378,638 Jan. 3, 1995
Mair et al. (Mair), “Equivalent Early Sensitivities of Myoglobin, Creatine Kinase
MB Mass, Creatine Kinase Isoform Ratios, and Cardiac Troponins I and T
for Acute Myocardial Infarction,” Clinical Chemistry, Vol. 41, No. 9, pp. 1266-
1272 (September 1995).
Ohman et al. (Ohman), “Early detection of acute myocardial infarction: additional
diagnostic information from serum concentrations of myoglobin in patients
without ST elevation,” British Heart Journal, Vol. 63, pp. 335-338 (1990).
Rabitzsch et al. (Rabitzsch), “Immunoenzymometric Assay of Human Glycogen
Phosphorylase Isoenzyme BB in Diagnosis of Ischemic Myocardial Injury,”
Clinical Chemistry, Vol. 41, No. 7, pp. 966-978 (July 1995).
Xu et al. (Xu), “Simultaneous Quadruple-Label Fluorometric Immunoassay of
Thyroid-Stimulating Hormone, 17"-Hydroxyprogesterone, Immunoreactive
Trypsin, and Creatine Kinase MM Isoenzyme in Dried Blood Spots,” Clinical
Chemistry, Vol. 38, No. 10, pp. 2038-2043 (October 1992).
ISSUES2
Claims 1-4, 7-9, 15-17, 20-22, 28-34, 40-45 and 51-54 stand rejected under
35 U.S.C. § 103(a) as being unpatentable over Deeg in view of Rutner. Claims 14, 27, 39
and 50 stand rejected under 35 U.S.C. § 103(a) as being unpatentable over Deeg in view
of Rutner as applied to claims 1-4, 7-9, 15-17, 20-22, 28-34, 40-45 and 51-54 above, and
further in view of Freundlich taken with each of Ohman, Mair and Rabitzsch. Claims 10-13,
23-26, 35-38 and 46-49 stand rejected under 35 U.S.C. § 103(a) as being unpatentable
over Deeg in view of Rutner as applied to claims 1-4, 7-9, 15-17, 20-22, 28-34, 40-45 and
51-54 above, and further in view of Freundlich in view of Diamandis and Xu. We reverse
According to the advisory action (Paper 22, mailed December 27, 1999), the examiner withdrew2
the final rejection of claims 1-4, 7-17 and 20-54 under 35 U.S.C. § 112, first paragraph, in view of appellants’
RESPONSE AFTER FINAL (Paper 21, filed November 30, 1999).
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