LAGRANGE et al v. KONRAD et al - Page 51




                 Patent Interference No. 103,548                                                                                                 
                 suggests very similar oxidation mechanisms for indoles and indolines in the context of                                          
                 oxidative hair dyeing and that suggestion buttresses the conclusion of obviousness with                                         
                 respect to using the Grollier ‘500 oxidation system with the indolines of Konrad claims 1-                                      
                 4.                                                                                                                              
                         Lagrange’s arguments to the contrary having been addressed, we conclude that,                                           
                 to one with ordinary skill in the art Lagrange’s claims 22-23 would have been prima                                             
                 facie obvious to one with ordinary skill in this art over Konrad claims 1-4 in view of the                                      
                 facts that:                                                                                                                     
                     · Grollier 500 teaches using the oxidation system, albeit with phenylenediamine,                                            
                         with indoles;                                                                                                           
                     · FR ‘061, like Grollier ‘500, teaches using an iodide/peroxide oxidizing system                                            
                         with indoles but without phenylenediamine; and,                                                                         
                     · Parent suggests equivalent oxidation mechanisms for indoles and indolines in                                              
                         the context of oxidative hair dyeing.                                                                                   
                 Discussion: Objective Evidence                                                                                                  
                         Lagrange's initial declaration evidence as to this issue, Cotteret Declaration II,                                      
                 was addressed in the Decision on Motions (paper no. 49, pp. 14-18), where it was found                                          
                 to have problems. Notwithstanding the parties' responses to the problems, we find the                                           
                 evidence unpersuasive as to the nonobviousness of the Lagrange claims.                                                          
                         Lagrange (LOB 32-35) seeks to overcome the prima facie case by providing                                                
                 objective evidence showing unexpected results using the claimed oxidizing system                                                
                 when dyeing with indolines. In support thereof, Lagrange has submitted Cotteret                                                 
                 Declaration II (see Part II of Cotteret Declaration II, paper no. 35).                                                          
                         Uptake results for C0 with an oxidizing system of iodide/peroxide, metal salt or                                        
                 parabenzoquinone have been compared to results obtained using a system consisting                                               

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