Appeal No.1997-0466
Application 08/154,158
Claims 49 and 53 are illustrative of the claims on appeal:
49. A kit for treating prostatic hypertrophy in living mammals, comprising:
sterile sealed vials containing at least one separate injectable unit-dosage of
a composition comprising a therapeutically effective concentration of collagenase and
hyaluronidase;
the concentration of the collagenase and hyaluronidase being effective to
cause the dissolution and regression of obstructive, hypertrophied, living prostatic tissue;
the concentration of the hyaluronidase being bout 1,600 to about 160,000 U/ml;
all provided in a pharmaceutically acceptable aqueous carrier suitable for
injection into living mammals.
53. A composition for treating prostatic hypertrophy in living mammals,
comprising:
a therapeutically effective concentration of collagenase and a therapeutically
effective concentration of hyaluronidase, the composition being suitable for administration
by direct intraprostatic injection;
the concentration of the collagenase and hyaluronidase being effective to
cause the dissolution and regression of obstructive, hypertrophied, living prostatic tissue;
the concentration of the hyaluronidase being about 1,600 to about 160,000 U/ml.
The prior art references relied upon by the examiner are:
Pinnell 4,645,668 February 24, 1987
Longo et al. (Longo) “Collagenase as an Adjunct to cryoprostatectomy,” Gordon & Breach,
pp. 113-120 (1972).
Cawston et al. (Cawston) “Methods in Enzymology,” Lorand Academic Press,” Vol. 80,
p. 711-723 (1981)
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