Appeal No.1997-0466
Application 08/154,158
infiltration of subcutaneously administered fluids. The examiner suggests that it is well
known that connective tissue contains hyaluronic acid, the substance on which
hyaluronidase acts.
Longo discloses a composition of collagenase for injection into frozen prostate
tissue for the purpose of degrading or decomposing cryo-slough. Baert is indicated to
establish the conventional use of antibiotics for injection into and for the treatment of the
prostate.
The examiner suggests that Longo motivates one to treat benign prostatic
hypertrophy with collagenase, and that one of ordinary skill in the art would be motivated to
include hyaluronidase for the purpose of increasing the infiltration of the collagenase into
the prostate and would have been further motivated to include the antibiotics as such as
claimed for the prophylaxis of bacterial prostatitis. Answer, page 6. However, Longo and
Baert fail to overcome the deficiencies of Pinnell and its failure to disclose the claimed
concentration of hyaluronidase. A prima facie case of obviousness has not been
established by the examiner. The rejection is reversed.
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