Appeal No. 1997-2204
Application No. 08/440,989
wherein R1 is (C1-C5)alkyl, C3-C6(cycloalkyl)alkyl, C5-C7(cycloalkenyl)alkyl, (C6-C10)aryl,
(C6-C10)aryl(C1-C5)alkyl, trans(C4-C5)alkenyl, allyl or furan-2-ylalkyl; R2 is H, OH or O2C(C1-
C5)alkyl; R3 is H, (C1-C5) alkyl, or ((C1-C5)alkyl)C=O; and R4 and R5 are individually H, F, Cl,
Br, NH2, NO2, (C1-C5) alkyl or (C1-C5) alkoxy or R4 and R5 together are benzo or
dioxymethylene; and the pharmaceutically acceptable salts thereof, wherein the amount is
effective to block L-opioid receptors in said tissue.
THE REFERENCES
In rejecting claim 21 on prior art grounds, the examiner relies on this reference:
Portoghese et al., “Role of the spacer in conferring K opioid receptor selectivity to bivalent
ligands related to norbinaltorphimine,” J. Med. Chem., Vol. 34, No. 4, pp. 1292-1296
(1991)
In rejecting claim 21 on non-prior art grounds, the examiner relies on this reference:
Stillson et al. (Stillson), “The hindered phenols,” Journal American Chemical Soc., Vol. 67,
pp. 303-307 (1945)
2
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