Appeal No. 1997-2373
Application No. 08/333,880
at least one multiport injection valve connecting said sample
solution input means to said column,
a second liquid chromatography column in communication with a
said multiport injection valve, said second column being operative
successively with or alternatively to said first column,
at least one of said first and second columns being packed with a
particulate chromatography material comprising perfusive particles
which permit convective fluid transport both within and between the
particles, or non-porous particles, thereby to confer on said column
a chromatographically effective mobile phase transit time
therethrough less than five minutes,
pump means for providing variable pressure delivery of solutions to
said columns via a said multiport valve,
plural solution reservoirs,
a mixing valve, connecting said solution reservoirs to said columns,
operative to mix solutions from said reservoirs, and
program means for specifying a sequence of system control
programs, the mixing of solution by said mixing valve, and the
delivery of said mixed solution to said columns via a said multiport
injective valve.
29. An apparatus for the quantitative detection of proteins in a
sample, comprising
first and second multiport valves, each said valve comprising
a sample loop which holds a defined volume of sample and
connects two ports of said valve;
a liquid chromatography column in communication with a
said valve, said column being packed with a particulate
chromatography material comprising perfusive particles which
permit convective fluid transport both within and between the
particles, or non-porous particles, thereby to confer on said column
a chromatographically effective mobile phase transit time
therethrough less than five minutes;
a sample feed line in communication with each said valve;
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