Ex parte AFEYAN et al. - Page 5


                Appeal No. 1997-2373                                                                          
                Application No. 08/333,880                                                                    

                      The examiner also rejected claims 29-32 as obvious over Mowery and                      
                Afeyan.  Claims 29-32 require that part of the sample volume be passed directly               
                through a detector means and that another part of the sample be passed through                
                a chromatography column and the detector means.  The examiner argues that                     
                the language of the claims “reads on the device of Mowery wherein when the                    
                multiport valve is switched[,] a sample is forced out to the detector and a second            
                sample which was held in the sample loop goes to the chromatography column                    
                and subsequently to the detector.”  Examiner’s Answer, page 14.                               
                      “In proceedings before the Patent and Trademark Office, the Examiner                    
                bears the burden of establishing a prima facie case of obviousness based upon                 
                the prior art.”  In re Fritch, 972 F.2d 1260, 1265, 23 USPQ2d 1780, 1783 (Fed.                
                Cir. 1992).  “‘Obviousness cannot be established b y combining the teachings of               
                the prior art to produce the claimed invention, absent some teaching or                       
                suggestion supporting the combination. Under section 103, teachings of                        
                references can be combined only if there is some suggestion or incentive to do                
                so.’ Although couched in terms of combining teachings found in the prior art, the             
                same inquiry must be carried out in the context of a purported obvious                        
                ‘modification’ of the prior art.  The mere fact that the prior art may be modified in         
                the manner suggested b y the Examiner does not make the modification obvious                  
                unless the prior art suggested the desirability of the modification.”  Id. at 1266,           
                23 USPQ2d at 1783 (citations omitted, emphasis in original).                                  
                      Here, the examiner has acknowledged that both the Cazer apparatus and                   
                the Mowery apparatus must be modified in order to meet the limitations of the                 


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