Appeal No. 1997-2373
Application No. 08/333,880
detector means in communication with said column for
detecting output; and
control means for operating said multiport valves to switch
between
a collection line comprising said sample feed line,
wherein plural sample volumes are introduced into said
sample loops and
a detection line comprising said chromatography
column, wherein one sample volume is passed directly
through said detector means and another is passed through
said column and said detector means.
The examiner relies on the following references:
Mowery Jr. 4,271,697 Jun. 09, 1981
Cazer et al. (Cazer) 5,071,547 Dec. 10, 1991
Afeyan et al. (Afeyan), “Perfusion Chromatography, An Approach to
Purifying Biomolecules,” Bio/Technology, Vol. 8, pp. 203-206 (1990)
Claims 1, 2, 4, 5, 19, 20, and 22-28 stand rejected under 35 U.S.C. § 103
as obvious over the combined disclosures of Cazer and Afeyan.
Claims 29-32 stand rejected under 35 U.S.C. § 103 as obvious over the
combined disclosures of Mowery and Afeyan.
We reverse.
Discussion
The claims are directed to a chromatographic apparatus having, inter alia,
a chromatography column comprising “a particulate chromatography material
comprising perfusive particles,” together with the other features set out in
representative claims 1 and 29. The examiner rejected claims 1, 2, 4, 5, 19, 20,
and 22-28 as obvious over Cazer and Afeyan, and rejected claims 29-32 as
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