Appeal No. 1997-2393
Application No. 08/183,381
Claim 1 is illustrative of the subject matter on appeal and is reproduced below:
1. A method of stimulating an immune response in a human against
malignant cells or an infectious agent, which comprises the step of
administering to said human an immunogenic amount of a baboon anti-
idiotype antibody or antibody fragment that acts as an immunogenic
functional mimic of an antigen that is a marker for a malignant cell or an
infectious agent.
The references relied upon by the examiner are:
Thornton et al. (Thornton) 4,908,203 Mar. 13, 1990
Hellstrom et al. (Hellstrom) 4,918,164 Apr. 17, 1990
Rubinstein et al. (Rubinstein) 5,101,017 Mar. 31, 1992
Haagensen et al. (Haagensen), “Evaluation of baboon antiserum to
carcinoembryonic antigen,” Clinical Chemistry, Vol. 26, pp. 1787-1790 (1980)
Huberman et al. (Huberman), “Non-human primate (Baboon) anti-carcinoembryonic
antigen antibody infusion in patients with metastatic adenocarcinoma,” Cancer
Immunol. Immunother., Vol. 23, pp. 137-142 (1986)
Estabrook et al. (Estabrook), “Non-human primate (Baboon) anti-gross cystic
disease fluid protein-15 antibody infusion in four women with metastatic breast
carcinoma,” Cancer Immunol. Immunother., Vol. 23, pp. 143-147 (1986)
Herlyn et al. (Herlyn), “Anti-idiotype immunization of cancer patients: Modulation of
the immune response,” Proc. Natl. Acad. Sci, USA, Vol. 84, pp. 8055-8059 (1987)
Hoffman et al. (Hoffman), “Naturally acquired antibodies to sporozoites do not
prevent malaria: vaccine development implications,” Science, Vol. 237, pp. 639-
642 (1987)
Barnes, “Obstacles to an AIDS vaccine,” Science, Vol. 240, pp. 719-721 (1988)
Klein et al. (Klein), “Effects of anti-antibodies on radiolabeled antibody therapy,”
Antibody, Immunoconjugates and Radiopharmaceuticals, Vol. 1, pp. 55-64 (1988)
Bloom, “Vaccines for the Third World,” Nature, Vol. 342, pp. 115-120 (1989)
Butcher, “Mechanisms of immunity to malaria and the possibilities of a blood-stage
vaccine: a critical appraisal,” Parasitology, Vol. 98, pp. 315-327 (1989)
Monestier et al. (Monestier), “Syngeneic anti-idiotype monoclonal antibodies to
murine anticarcinoembryonic antigen monoclonal antibodies,” Cancer Research,
Vol. 49, pp. 123-126 (1989)
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