Ex parte GOLDENBERG et al. - Page 6


                  Appeal No.  1997-2393                                                                                     
                  Application No. 08/183,381                                                                                
                  induced protective immunity against the original [Trypanosoma] antigenic variant to                       
                  which the Ab1 was directed.”                                                                              
                         It is well settled that the examiner bears the initial burden of providing                         
                  reasons why a supporting disclosure does not enable a claim.  In re Marzocchi, 439                        
                  F.2d 220, 223, 169 USPQ 367, 369 (CCPA 1971).  In this regard we direct the                               
                  examiner’s attention to the courts statements in Atlas Powder Co. v. E.I. DuPont De                       
                  Nemours & Co., 750 F.2d 1569, 1576-77, 224 USPQ 409, 414 (Fed. Cir. 1984)                                 
                  that:                                                                                                     
                                Even if some of the claimed combinations were inoperative,                                  
                                the claims are not necessarily invalid.  “It is not a function of the                       
                                claims to specifically exclude ... possible inoperative                                     
                                substances ....”  In re Dinh-Nguyen, 492 F.2d 856, 859-59, 181                              
                                USPQ 46, 48 (CCPA 1974)(emphasis omitted).  Accord, In re                                   
                                Geerdes, 491 F.2d 1260, 1265, 180 USPQ 789, 793 (CCPA                                       
                                1974); In re Anderson, 471 F.2d 1237, 1242, 176 USPQ 331,                                   
                                334-35 (CCPA 1971).  Of course, if the number of inoperative                                
                                combinations becomes significant, and in effect forces one of                               
                                ordinary skill in the art to experiment unduly in order to practice                         
                                the claimed invention, the claims might indeed be invalid.  See,                            
                                e.g., In re Cook, 439 F.2d 730, 735, 169 USPQ 298, 302                                      
                                (CCPA 1971).                                                                                
                         On this record, the examiner has limited the scope of appellants’ generic                          
                  invention to AIDS, malaria and cancer.  In response to appellants’ citation to prior                      
                  art supporting the scope of their claims, the examiner argued (Answer,                                    
                  that “the scope of enablement is not met, for the recitation of preventing cancer or                      
                  infections, such as HIV or malaria as exemplified.”                                                       
                         In our opinion, the examiner failed to provide the evidence necessary to                           
                  demonstrate that appellants’ disclosure does not enable their claimed invention.                          
                  While some of the claimed combinations may be inoperative, the examiner failed to                         

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