Appeal No. 1997-2510 Application No. 07/868,539 corresponds to a sequence of DNA recognized by a viral-specific transcription factor is linked to a second region having a sequence of nucleotides complementary to said first region when the first and second regions are positioned in an anti-parallel orientation. In contrast, claim 1 of Inouye is drawn to a stem-loop structure (claim 1, part b) flanked on either side by a transcriptional promoter segment (claim 1, part a) and a gene segment (claim 1, part c). Accordingly, the sequence of DNA recognized by a viral-specific transcription factor (e.g. “transcriptional promoter segment”) is not part of the stem-loop structure, as is required by the instant claims. To establish a prima facie case of obviousness, there must be more than the demonstrated existence of all of the components of the claimed subject matter. There must be some reason, suggestion, or motivation found in the prior art whereby a person of ordinary skill in the field of the invention would make the substitutions required. That knowledge cannot come from the applicants' disclosure of the invention itself. Diversitech Corp. v. Century Steps, Inc., 850 F.2d 675, 678-79, 7 USPQ2d 1315, 1318 (Fed. Cir. 1988); In re Geiger, 815 F.2d 686, 688, 2 USPQ2d 1276, 1278 (Fed. Cir. 1987); Interconnect Planning Corp. v. Feil, 774 F.2d 1132, 1143, 227 USPQ 543, 551 (Fed. Cir. 1985). On the record before us, we find no reasonable suggestion for combining the teachings of the references relied upon by the examiner in a manner which 21Page: Previous 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 NextLast modified: November 3, 2007