Ex Parte CARMAN - Page 21



                    Appeal No. 1997-2510                                                                                                    
                    Application No. 07/868,539                                                                                              

                    corresponds to a sequence of DNA recognized by a viral-specific transcription                                           
                    factor is linked to a second region having a sequence of nucleotides                                                    
                    complementary to said first region when the first and second regions are                                                
                    positioned in an anti-parallel orientation.  In contrast, claim 1 of Inouye is drawn                                    
                    to a stem-loop structure (claim 1, part b) flanked on either side by a                                                  
                    transcriptional promoter segment (claim 1, part a) and a gene segment (claim 1,                                         
                    part c).  Accordingly, the sequence of DNA recognized by a viral-specific                                               
                    transcription factor (e.g. “transcriptional promoter segment”) is not part of the                                       
                    stem-loop structure, as is required by the instant claims.                                                              
                            To establish a prima facie case of obviousness, there must be more than                                         
                    the demonstrated existence of all of the components of the claimed subject                                              
                    matter.  There must be some reason, suggestion, or motivation found in the prior                                        
                    art whereby a person of ordinary skill in the field of the invention would make the                                     
                    substitutions required.  That knowledge cannot come from the applicants'                                                
                    disclosure of the invention itself.  Diversitech Corp. v. Century Steps, Inc., 850                                      
                    F.2d 675, 678-79, 7 USPQ2d 1315, 1318 (Fed. Cir. 1988); In re Geiger, 815                                               
                    F.2d 686, 688, 2 USPQ2d 1276, 1278 (Fed. Cir. 1987); Interconnect Planning                                              
                    Corp. v. Feil, 774 F.2d 1132, 1143,  227 USPQ 543, 551 (Fed. Cir. 1985).  On                                            
                    the record before us, we find no reasonable suggestion for combining the                                                
                    teachings of the references relied upon by the examiner in a manner which                                               






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