Ex parte BOZYCZKO-COYNE et al. - Page 2




              Appeal No. 1997-3275                                                                                        
              Application No. 07/963,329                                                                                  

                     The references relied upon by the examiner are:                                                      
              Fryklund et al. (Fryklund)          5,068,224                   Nov. 26, 1991                               
              Lewis et al. (Lewis)                5,093,317                   Mar. 03, 1992                               
              Sara                                0227619                     July  01, 1987                              
              (European Patent Application)                                                                               

              Fellows et al. (Fellows) " IGF-1 Supports Survival and Differentiation of Fetal Rat Brain                   
              Neurons In Serum-Free Hormone-Free Defined Medium," Soc. Neurosci. Abstr., Vol 13,                          
              1615 (1987)                                                                                                 
              Hansson et al. (Hansson) "Evidence indicating trophic importance of IGF-I in Regenerating                   
              peripheral nerves," Acta Physiol. Scand.,Vol. 126, pp. 609-614 (1986)                                       
              Ocrant et al. (Ocrant) "Localization and Structural Characterization of Insulin-Like Growth                 
              Factor Receptors in Mammalian Retina," Endocrinology, Vol. 125, No.5, pp. 2407-2413                         
              (1989)                                                                                                      
              Leeson "Histology" W.B. Saunders Company Third Edition, Philadelphia, Pa., pp. 554-                         
              565 (1976)                                                                                                  
              Fingl et al. (Fingl) "The Pharmacological Basis of Therapeutics," (L.S. Goodman et al.,                     
              eds.) Macmillan Publishing Company, pp. 1-46 (1975)                                                         
              Leschey et al. (Leschey) "Growth Factor Responsiveness of Human Retinal Pigment                             
              Epithelial Cells," Investigative Ophthalmology & Visual Science, Vol. 31, No. 5, pp. 839-                   
              846 (1988)                                                                                                  
              Yorek et al. (Yorek) "Amino Acid and Putative Neurotransmitter Transport in Human Y79                       
              Retinoblastoma Cells," The Journal of Biological Chemistry, Vol. 262, No. 23, pp. 10986-                    
              10993 (1987)                                                                                                






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