Ex parte MA et al. - Page 5




          Appeal No. 1997-3811                                        Page 5          
          Application No. 08/357,845                                                  


                          Rejections under 35 U.S.C. § 102                            
               The examiner has the initial burden of establishing a                  
          prima facie case of anticipation by pointing out where all of               
          the claim limitations are described in a single reference.                  
          See In re                                                                   
          Spada, 911 F.2d 705, 708, 15 USPQ2d 1655, 1657 (Fed. Cir.                   
          1990);                                                                      




          In re King, 801 F.2d 1324, 1327, 231 USPQ 136, 138-39 (Fed.                 
          Cir. 1986).  This the examiner has not done.                                
               All of the claims on appeal require a method of                        
          separating a specified quantity of the (+) and (-) enantiomers              
          of a racemic compound mixture from each other using high-speed              
          countercurrent                                                              
          chromatography.  The method of claim 1, the sole independent                
          claim on appeal, includes the following steps:                              
                    (a) adding a chiral selector to a first liquid                    
               phase of two pre-equilibrated immiscible liquid                        
               phases and charging a countercurrent chromatographic                   
               centrifuge column with said first liquid phase;                        









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