Ex parte MA et al. - Page 11




          Appeal No. 1997-3811                                       Page 11          
          Application No. 08/357,845                                                  

          would have reasonably conveyed to one having ordinary skill in              
          the art.  In re Young, 927 F.2d 588, 591, 18 USPQ2d 1089, 1091              
          (Fed. Cir. 1991); Merck & Co., Inc. v. Biocraft Laboratories,               
          Inc., 874 F.2d 804, 807, 10 USPQ2d 1843,1846 (Fed. Cir. 1989).              
               The difficulty we have with the examiner’s position stems              
          from the fact that the examiner has not offered a reasonable                
          explanation as to how the combined teachings of either                      
          Pirkle ‘440 or Pirkle ‘293 taken together with the admitted                 
          prior art and with or without Cahnmann would have reasonably                
          suggested carrying out the separation process by adding a                   
          chiral separator to the first liquid phase (stationary phase)2              
          and passing a second liquid phase through a countercurrent                  
          chromatographic centrifuge to elute the enantiomers therefrom.              
          Concerning this matter, we note that the examiner refers to                 
          portions of the applied Pirkle patents that make mention of                 
          using a chiral selector in a mobile phase (answer, page 11,                 
          lines 2-16).                                                                
               We agree with the examiner that both applied Pirkle                    
          patents particularly refer to the use of a chiral selector in               

               2 See specification at page 1, lines 9-12 and page 5, lines 7-11, for  
          example.                                                                    







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