Appeal No. 1997-4272 Application No. 08/429,053 speculation and assumptions is legal error.). Therefore, we vacate the rejection of claim 23 under 35 U.S.C. § 103. 2. Claim 11 The examiner rejected claim 11 as obvious over the combined teachings of Walker and Kalt-Torres. The examiner argues that those skilled in the art would have been led to combine the partially purified maize SPS enzyme of Kalt- Torres with the hybridoma-producing process of Walker with a reasonable expectation of obtaining hybridomas that secrete monoclonal antibodies specific for maize SPS. Examiner’s Answer, pages 6-7. The examiner does not allege that either reference discloses the specific hybridomas recited in the claim but argues that the claimed cell lines are obvious since the record does not contain any evidence that the cell lines differ in any significant manner or produce monoclonal antibodies that differ in any significant aspect from hybrid[oma] cell lines that one of ordinary skill in the art would expect to generate using an extract of maize as the starting antigen (Kalt-Torres et al.) in the basic method of Walker. Id., page 8. The examiner is correct that if the products made obvious by the prior art reasonably appear to be the same as those claimed, Appellants bear the burden of showing that they are not. See In re Spada, 911 F.2d 705, 708, 15 USPQ2d 1655, 1658 (Fed. Cir. 1990) (“[W]hen the PTO shows sound basis for believing that the products of the applicant and the prior art are the same, the applicant has the burden of showing that they are not.”). In this case, however, the examiner’s attempt to shift the burden of proof to Appellants was premature. 5Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 NextLast modified: November 3, 2007