Ex Parte VAN ASSCHE et al - Page 8


                 Appeal No. 1997-4272                                                                                   
                 Application No. 08/429,053                                                                             

                        More precisely a subject of the invention is the SPS of maize.                                  
                 Pages 1-2.  These statements are directed to the SPS enzyme itself rather than                         
                 to antibodies directed to SPS.  On page 5, however, the specification states that                      
                 “[a]lso a subject of the invention is monoclonal antibodies directed specifically                      
                 against the SPS.”  Taken together, all these statements suggest that the                               
                 inventors intended to claim patent rights to SPS enzymes, and antibodies                               
                 directed thereto, from all sources.  On the other hand, most of the specification                      
                 and all of the working examples are directed to various aspects of the maize SPS                       
                 enzyme.  Thus, the specification does not resolve the ambiguity of claim 24.                           
                        We next consider the prosecution history.  The application as filed                             
                 contained claims 1-22.  Claims 1-9 and 14-22 were cancelled by preliminary                             
                 amendment (Paper No. 3, filed April 26, 1995).  Original claims 12 and 13 were                         
                 replaced by claims 24 and 25 (in Paper No. 5, filed April 26, 1995), which read as                     
                 follows:                                                                                               
                        24.  A monoclonal antibody directed specifically against proteins having                        
                             saccharose phosphate synthetase (SPS) activity.                                            
                        25.  A monoclonal antibody of claim 24 directed against maize (SPS).                            
                        The scope of claims 24 and 25, as originally filed, was clear: claim 24                         
                 encompassed antibodies directed against any SPS enzyme, and claim 25 was                               
                 limited to antibodies directed against maize SPS.                                                      
                        Further amendments, however, confused the issue.  First, claim 24 was                           
                 amended to add the Sequence ID limitations, so that the claims then read as                            
                 follows:                                                                                               


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