Ex Parte LANGE et al - Page 9




              Appeal No. 1998-0900                                                                                        
              Application No. 08/290,047                                                                                  

              apparent focus of the homologous relationship between the claimed and prior art                             
              compounds.                                                                                                  
                     From the statement of the rejection, as well as the discussion at pages 12-14 of                     
              the Examiner's Answer, which focuses on the compounds disclosed by Wagner, it is                            
              reasonable to conclude that the examiner regards the compounds of Wagner as being                           
              the most closely related to the claimed compounds.  The examiner concludes that                             
              (Answer, page 11):                                                                                          
                            it would be obvious to one or ordinary skill in the art that                                  
                            homologous compounds having an alkyl substituent on the                                       
                            alpha carbon of the amino acid moieties would possess a                                       
                            community of properties in common. . . . Those of ordinary                                    
                            skill in the art [would] readily recognize that compounds                                     
                            having asymmetric carbon atoms possess optical isomers.                                       
                            (Citation omitted).                                                                           
                     Appellants' principal argument as to whether the examiner has established a                          
              prima facie case of obviousness, focuses on the fact that none of the references                            
              mention optically active compounds or appreciate the importance of optical activity to                      
              the claimed invention.  As stated above, the examiner has urged that the presence of                        
              an asymmetric carbon atoms in the prior art compounds would have suggested that the                         
              compounds exist as optical isomers.  The examiner has, additionally, argued that "the                       
              claims have no requirement that is supported in the specification as to the purity of the                   
              claimed compounds and as such reads on any composition containing the recited                               
              compounds including mixtures of the compound with its optical isomers." (Answer, page                       
              11).                                                                                                        
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