Ex parte BASINSKI et al. - Page 2


                 Appeal No. 1999-1676                                                                                    
                 Application No. 08/452,228                                                                              

                        Claims 1 and 3 are illustrative of the subject matter on appeal and are                          
                 reproduced below:                                                                                       

                        1. An isolated protein nucleic acid molecule consisting of a nucleotide                          
                            sequence that encodes a protein having the following amino acid                              
                            sequence:                                                                                    
                            NH2-Val Pro Ile Gln Lys Val Gln Ser Asp Thr Lys Thr Leu  Ile                                 
                            Lys  Thr Ile Val Thr Arg  Ile Asn Asp Ile       Ser His Thr Gln Ser                          
                            Val Ser Ser Lys Gln Arg Val Thr Gly Leu Asp Phe Ile Pro Gly                                  
                            Leu His Pro Val Leu Thr Leu Ser Gln Met Asp Gln Thr Leu Ala                                  
                            Ile  Tyr Gln Gln Ile Leu Ile Asn Leu Pro Ser Arg Asn Val Ile                                 
                            Gln Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Leu                                  
                            Leu Ala Phe Ser Lys Ser Cys His Leu Pro Leu Ala Ser Gly Leu                                  
                            Glu Thr Leu Glu Ser Leu Gly Asp Val Leu Glu Ala Ser Leu Tyr                                  
                            Ser Thr Glu Val Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln                                  
                            Asp Met Leu Trp Gln Leu Asp Leu Ser Pro Gly Cys-COOH                                         
                            (SEQ ID NO: 2).                                                                              
                        3. A recombinant DNA vector comprising a nucleic acid molecule of [c]laim                        
                            1.                                                                                           
                        The references relied upon by the examiner are:                                                  
                 Martial et al. (Martial), “Human Growth Hormone: Complementary DNA Cloning and                          
                 Expression in Bacteria,” Science, Vol. 205, pp. 602-607 (1979)                                          
                 Zhang et al. (Zhang), “Positional cloning of the mouse obese gene and its human                         
                 homologue,” Nature, Vol. 372, pp. 425-429 (1994)                                                        

                                             GROUNDS OF REJECTION                                                        
                        Claims 1 and 2 stand rejected under 35 U.S.C. § 103, as being unpatentable                       
                 over Zhang.                                                                                             
                        Claims 3-8 stand rejected under 35 U.S.C. § 103, as being unpatentable                           
                 over Zhang in view of Martial.                                                                          
                        We reverse.                                                                                      



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