Ex parte BASINSKI et al. - Page 6


                 Appeal No. 1999-1676                                                                                    
                 Application No. 08/452,228                                                                              
                 practicing the claimed invention, a suggestion to modify the prior art to practice the                  
                 claimed invention, and evidence suggesting that it would be successful.”                                
                        Since there are no per se rules of obviousness or nonobviousness, each                           
                 case must be decided upon the facts in evidence in that case.  See In re Cofer, 354                     
                 F.2d 664, 667, 148 USPQ 268, 271 (CCPA 1966)(“[n]ecessarily it is facts                                 
                 appearing in the record, rather than prior decisions in and of themselves, which                        
                 must support the legal conclusion of obviousness under 35 U.S.C. § 103”); and Ex                        
                 parte Goldgaber,  41 USPQ2d 1172, 1176 (Bd. Pat. App. & Int. 1995) (“each case                          
                 under 35 U.S.C § 103 is decided on its own particular facts”).                                          
                        Considering the facts on this record, appellants argue (Brief, bridging                          
                 paragraph, pages 5-6) that “[t]he studies in Zhang do not indicate that an OB                           
                 homolog exists in rhesus monkeys because genomic DNA from monkeys is not                                
                 included in the blot.”  Appellants further argue (Brief, page 7) that Zhang provides                    
                 “no information regarding probe content or specific hybridization conditions that                       
                 would enable one to clone the rhesus ob cDNA and identify the corresponding                             
                 protein.  It is often quite difficult to predict whether a particular probe will work, under            
                 a certain set of hybridization conditions, to clone a particular gene.”                                 













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