Ex parte CAREY et al. - Page 7




            Appeal No. 1999-1703                                                                              
            Application No. 08/313,194                                                                        



                   With respect to claim 13, the examiner has not provided any reasoned analysis why          
            it would have been obvious to one of ordinary skill in the art to combine the claimed             
            angiotensin II antagonists with one or more pharmaceutical agents selected from aldose            
            reductase inhibitors and hypoglycaemic agents.   In the rejection under 35 U.S.C. § 103(a)        
            the examiner has failed to even address composition claim 13 separate from the method             
            claims.                                                                                           
                   After evidence or arguments are submitted by the appellants in response to                 
            rejection based on obviousness, patentability is determined on the totality of the record, by     
            a preponderance of evidence with due consideration to persuasiveness of the argument.             
            On balance, we believe that the totality of the evidence presented by the examiner and            
            appellants weighs in favor of finding the claimed invention to be non-obvious in view of the      
            cited references.   We find the examiner has not established on the record before us that         
            the cited references both suggest the claimed subject matter and reveal a reasonable              
            expectation of success to one reasonably skilled in the art.  The rejection of claims 1-5 and     
            13 for obviousness of the claimed invention is reversed.                                          


            35 U.S.C. 112, first paragraph                                                                    
                   Claim 13 stands rejected under 35 U.S.C. 112, first paragraph, as containing               
            subject matter which was not described in the specification in such a way as to enable one        

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