Ex parte CAREY et al. - Page 8




            Appeal No. 1999-1703                                                                              
            Application No. 08/313,194                                                                        



            skilled in the art to which it pertains or with which it is most nearly connected to make         
            and/or use the invention.                                                                         
                   The examiner argues that the specification lacks a teaching of the amounts and             
            which aldose reductase inhibitor or hypoglycaemic agents are to be used in applicants'            
            claimed invention.  Answer, page 3.                                                               
                   Appellants respond to this argument, stating that                                          
                   The invention of claim 13 lies in recognizing that A-II antagonists are                    
                   useful in combination with other known agents used for treating or preventing              
                   impaired neuronal conduction velocity...   [P]ersons skilled in the art wishing            
                   to treat or prevent impairment of neuronal conduction velocity could easily                
                   select a suitable known aldose reductase inhibitor or hypoglycaemic agent,                 
                   and could readily select a suitable quantity to be used in the combination of              
                   claim 13.                                                                                  
            Brief, page 16.                                                                                   
                   The examiner fails to directly respond to the argument of appellants that persons          
            skilled in the art wishing to treat or prevent impairment of neuronal conduction velocity         
            could easily select a suitable known aldose reductase inhibitor or hypoglycaemic agent,           
            and could readily select a suitable quantity to be used in the combination of claim 13,           
            stating only that “there are various unrelated compounds which are so classified and there        
            is a lack of teaching in the specification of which species would have the claimed effect.”       
            Answer, page 4.                                                                                   



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