SHIOKAWA et al. V. MAIENFISCH et al. - Page 54




                claimed compounds fall within the scope of the preferred heterocyclic compounds of JP ‘943.                             

                Similarly, Maienfisch’s claimed compositions and methods, with the exception of the tautomers, fall                     

                within the scope of compositions and methods described by JP ‘943.  JP ‘943, however, does not                          

                literally describe a 1,3,5-oxadiazine heterocyclic compound nor would such a compound be                                

                immediately envisioned from the JP ‘943 disclosure.  Yet, the JP ‘943 disclosure does suggest that                      

                certain classes of heterocyclic compounds, such as Maienfisch’s claimed oxadiazines, would be                           

                effective as insecticides.                                                                                              

                Thus, given the JP ‘943 disclosure, it may have been prima facie obvious to one of ordinary skill in the                

                art to form Maienfisch’s claimed 1,3,5 oxadiazines with the expectation that such compounds would                       

                function as effective insecticides.                                                                                     

                       Additionally, we note that Maienfisch’s parent ‘931 application specifically claimed a pest-                     

                resistant plant propagation material having 1,3,5-oxadiazines.  The claimed 1,3,5-oxadiazine containing                 

                material was rejected as obvious over Shiokawa’s parent ‘589 patent.  (SX 2063, pages 3-4).  In                         

                making the obviousness rejection the examiner stated that:                                                              

                               It is noted that the closest compound disclosed in Shiokawa is compound no.                              
                       23 at Col. 13.  The claimed compounds differ from this compound only by the                                      
                       replacement of the sulfur ring atom with an oxygen atom.  These two atoms are taught                             
                       to be equivalent at this position at Col. 1, line 30 in the formula I compounds.  Thus,                          
                       one skilled in the art would have been motivated to replace the sulfur atom with an                              
                       equivalent oxygen atom with the expectation that such similar compounds would                                    
                       possess similar insecticidal activity.                                                                           
                               If applicants intend to present evidence of unexpected insecticidal results, such                        
                       testing should be comparative with closest compound in Shiokawa, i.e. compound 23                                
                       therein.                                                                                                         

                (SX 2063, p. 4).                                                                                                        


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