VISSER et al v. HOFVANDER et al - Page 127




          Interference 103,579                                                        
               applications start at the same basepair.  As admitted                  
               by Dr. Bruinenberg during cross examination, that                      
               statement is wrong.  The Hergersberg 275 basepair                      
               fragment in an antisense direction would start with 243                
               and go backwards, while Sequence ID No. 1 of Hofvander                 
               would start at base pair 342 and go backwards. . . . .                 
                    8.  Dr. Bruinenberg’s statement that the Hergersberg              
               antisense sequence discloses 80% of Hofvander Sequence                 
               ID No. 1 was also admitted to be wrong.  Further, the                  
               statement that the “extra 20 percent of Hofvander sequence             
               ID No. 1 are promoter sequences, i.e., noncoding DNA                   
               sequences” was also admitted to be wrong. . . . .                      
                    9.  Dr. Bruinenberg incorrectly identified leader                 
               sequence in both Hergersberg (pages 28-29)(HX 41) and                  
               in SEQ ID No. 1 of Hofvander (HX 40) as being promoter                 
               sequence. . . . .                                                      
                    10.  Even Dr. Bruinenberg could not believe the                   
               errors in his Declaration . . . .                                      
          Visser responds to Hofvander’s arguments as follows (Paper                  
          No. 134, p. 6):                                                             
                    [A]lthough Hofvander has only moved to suppress                   
               paragraph 11 of the Bruinenberg Declaration, Hofvander                 
               opines that the Bruinenberg Declaration as a whole has                 
               been shown to be unreliable.  The basis for contending                 
               that the declaration as a whole is unreliable is set                   
               forth in paragraphs 6-10 of Hofvander’s statement of                   
               material facts.  Although Dr. Bruinenberg admittedly                   
               made errors in other portions of the Bruinenberg                       
               Declaration, this is not a reasonable basis for                        
               concluding that the test results set forth in                          
               paragraph 11 of the Bruinenberg Declaration are                        
               unreliable.                                                            
               We agree with Visser that Hofvander’s motion to suppress               
          evidence is primarily directed to paragraph 11 of the Bruinenberg           
          Declaration.  To the extent Hofvander argues that Bruinenberg’s             
          Declaration is as whole unreliable, we find that the argument               

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