Ex Parte OKAMOTO et al - Page 13




          Appeal No. 2000-0132                                                        
          Application No. 08/934,791                                                  

          described in the Rule 132 declaration executed by Mr. Ichida and            
          Mr. Ikeda on September 1, 1995.  In any event, we find that these           
          particles are not limited to any particular shapes and are known            
          to include those in the form of beads.  Moreover, it is well                
          known to use sorbents, including cellulose sorbents, in the form            
          of beads in chromatography separation.  See, e.g., Determann,               
          column 2, lines 1-5 and Schaeffer, column 2, lines 15-20.                   
               Given these teachings, we concur with the examiner that one            
          of ordinary skill in the art would have been led to employ                  
          cellulose triphenyl carbamate particles, including those in the             
          form of beads, in a chromatographic column, with a reasonable               
          expectation of successfully using them in chromatography                    
          separation.  Hence, we conclude that the examiner has established           
          a prima facie case of obviousness regarding the subject matter of           
          claims 22 and 25.  In reaching this conclusion, we also note that           
          the appellants “do not dispute that Mikes combined with Hagel               
          would suggest to one of ordinary skill in the art that cellulose            
          trisphenylcarbamate could be used as a separating agent in a                
          chromatographic column.”  See the Brief, page 10.                           
               However, we determine that claims 21, 23, 44 and 46 are on             
          different footing.  Although these claims require that cellulose            
          triphenyl carbamate be supported on a carrier, the examiner does            

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