Appeal No. 2000-0132 Application No. 08/934,791 described in the Rule 132 declaration executed by Mr. Ichida and Mr. Ikeda on September 1, 1995. In any event, we find that these particles are not limited to any particular shapes and are known to include those in the form of beads. Moreover, it is well known to use sorbents, including cellulose sorbents, in the form of beads in chromatography separation. See, e.g., Determann, column 2, lines 1-5 and Schaeffer, column 2, lines 15-20. Given these teachings, we concur with the examiner that one of ordinary skill in the art would have been led to employ cellulose triphenyl carbamate particles, including those in the form of beads, in a chromatographic column, with a reasonable expectation of successfully using them in chromatography separation. Hence, we conclude that the examiner has established a prima facie case of obviousness regarding the subject matter of claims 22 and 25. In reaching this conclusion, we also note that the appellants “do not dispute that Mikes combined with Hagel would suggest to one of ordinary skill in the art that cellulose trisphenylcarbamate could be used as a separating agent in a chromatographic column.” See the Brief, page 10. However, we determine that claims 21, 23, 44 and 46 are on different footing. Although these claims require that cellulose triphenyl carbamate be supported on a carrier, the examiner does 13Page: Previous 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 NextLast modified: November 3, 2007