Ex Parte OKAMOTO et al - Page 14




          Appeal No. 2000-0132                                                        
          Application No. 08/934,791                                                  

          not indicate that Hagel and Mikes individually, or in                       
          combination, teach or suggest such a feature.  Hence, we conclude           
          that the examiner has not established a prima facie case of                 
          obviousness regarding the subject matter of claims 21, 23, 44 and           
          46.                                                                         
               Recognizing the deficiency of Hagel and Mikes, the examiner            
          further relies on Schaeffer to reject claims 21 and 23 under                
          35 U.S.C. § 103.7  We find that Schaeffer teaches that                      
          polysaccharide separating agents can be covalently bonded to any            
          inorganic support, including glass beads, to provide a high                 
          degree of purification with high flow rates in chromatographic              
          separation.  See column 2, lines 8-25, together with column 1,              
          lines 15-40.  The polysaccharide separating agents generically              
          described in Schaeffer include the polysaccharide separating                
          agent, i.e., cellulose triphenyl carbamate, described in Hagel.             
          See, e.g., Schaeffer, column 1, lines 15-17.                                
               Thus, the appellants’ arguments to the contrary                        
          notwithstanding, we determine that one of ordinary skill in the             
          art would have been led to employ an inorganic carrier, such as             


               7 We note that the examiner carelessly left out claims                 
          44 and 46 in this rejection.  In the event of further                       
          prosecution, the examiner should include claims 44 and 46 in this           
          rejection.                                                                  
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