Ex Parte KEENE et al - Page 6



                  Appeal No. 2000-2269                                                           Page 6                    
                  Application No. 08/862,337                                                                               

                  972 F.2d 1260, 1265, 23 USPQ2d 1780, 1783 (Fed. Cir. 1992).  “Although                                   
                  couched in terms of combining teachings found in the prior art, the same inquiry                         
                  must be carried out in the context of a purported obvious ‘modification’ of the                          
                  prior art.  The mere fact that the prior art may be modified in the manner                               
                  suggested by the Examiner does not make the modification obvious unless the                              
                  prior art suggested the desirability of the modification.”  Id. at 1266, 23 USPQ2d                       
                  at 1783 (citations omitted).                                                                             
                         We agree with Appellants that the examiner has not carried his burden of                          
                  showing that the claims are prima facie obvious over the prior art.  We note                             
                  initially that the basis of the examiner’s rejection is somewhat difficult to discern,                   
                  because he did not address the particular limitations of any specific claim.  For                        
                  example, the examiner noted that Gold differs from the claimed invention in that                         
                         Gold does not explicitly teach the collection of antibodies from                                  
                         individuals, with whatever malady, for use in the assay.  Gold also                               
                         does not explicitly teach specific Kd values, all possible specific                               
                         buffer conditions, or selection of nucleic acids which can compete                                
                         for binding with an antigen at an antibody target site.                                           
                  Examiner’s Answer, pages 4-5.  None of these limitations, however, appears in                            
                  independent claims 1 or 26.                                                                              
                         With respect to claims 1 and 26, the examiner has not identified any                              
                  specific difference between what is claimed and what is disclosed in the prior art,                      
                  nor has he provided any reasoning as to why the difference(s) would have been                            
                  obvious to those skilled in the art.  Thus, on this record, we cannot say that the                       
                  examiner has carried his burden of showing that a person skilled in the art would                        






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