Ex Parte HERSH - Page 2


                  Appeal No. 2001-1177                                                           Page 2                    
                  Application No. 08/781,868                                                                               


                         36.    The composition of claim 35 further comprising acetyl-L-carnitine.                         
                         39.    The composition of claim 35 further comprising epidermal growth                            
                                factor.                                                                                    
                         43.    The composition of claim 35 further comprising tissue respiratory                          
                                factor.                                                                                    
                         45.    A method for enhancing repair from free radical damage to skin as                          
                                a result of treatment of the skin with exfoliants, chemosurgery or                         
                                laser therapy comprising topically applying active ingredients in a                        
                                suitable topical carrier to skin damaged by exfoliants,                                    
                                chemosurgery or laser therapy, said active ingredients comprising                          
                                glutathione and selenoamino acid in amounts suitable for                                   
                                enhancing repair of skin from free radical damage.                                         
                         The examiner relies on the following references:                                                  
                  Levin                              4,942,031                   Jul.  17, 1990                          
                  Spector et al. (Spector)            5,128,365                   Jul.    7, 1992                         
                  Burke                              5,330,757                   Jul.  19, 1994                          
                  Finkenaur et al. (Finkenaur)        5,427,778                   Jun. 27, 1995                           
                  N’Guyen et al. (N’Guyen)            5,516,507                   May 14, 1996                            
                  Piazza et al. (Piazza)              5,565,439                   Oct. 15, 1996                           
                  Otsu et al. (Otsu)                 5,582,817                   Dec.10, 1996                            
                  Cavazza et al. (Cavazza)            5,627,212                   May    6, 1997                          
                  Hersh et al. (Hersh)                5,667,791                   Sep. 16, 1997                           
                         Claims 35, 36, and 38 stand rejected for obviousness-type double                                  
                  patenting over claims 1, 3, and 5-7 of Hersh.                                                            
                         Claims 35-54 stand rejected under 35 U.S.C. § 102(e) as anticipated by                            
                  Hersh.                                                                                                   
                         Claims 35, 37, 38, and 44 stand rejected under 35 U.S.C. § 103 as                                 
                  obvious in view of N’Guyen and Burke.                                                                    
                         Claims 36 and 39-43 stand rejected under 35 U.S.C. § 103 as obvious in                            
                  view of N’Guyen and Burke, combined with one of the following references:                                
                  Cavazza, Piazza, Otsu, Levin, Finkenauer, or Spector.                                                    





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