Ex Parte HERSH - Page 3


                  Appeal No. 2001-1177                                                           Page 3                    
                  Application No. 08/781,868                                                                               

                         Claims 45-54 stand rejected under 35 U.S.C. § 103 as obvious in view of                           
                  N’Guyen, Burke, Cavazza, Piazza, Otsu, Levin, Finkenauer, and Spector.                                   
                         We affirm the rejection of the composition claims (claims 35-44) but                              
                  reverse the rejection of the method claims (claims 45-54).                                               
                                                       Background                                                          
                         “Skin peeling programs (chemical or thermal peels) are designed to                                
                  remove ‘dead’ skin with the aim of being replaced by new, clearer and younger                            
                  cells yielding smooth and firmer skin.”  Specification, page 1.  Such therapies are                      
                  used to treat, among other things, sun-damaged skin and fine lines.  See id.                             
                  However, these therapies can also result in damage to the skin, resulting from                           
                  the generation of free radicals.  See id., page 8.                                                       
                         The specification discloses “a composition and method for reducing the                            
                  cutaneous effects and complications of chemosurgery and laser therapy of                                 
                  induced skin damage.  The composition comprises an effective amount of a                                 
                  glutathione and selenoamino acid since selenium is a co-factor of glutathione                            
                  peroxidase.”  Page 13.  The specification also discloses that the “composition                           
                  can be formulated as a lotion containing from about 0.01% to 10% of the above                            
                  described active ingredients.”  Page 27.  The specification discloses several                            
                  exemplary compositions that contain 0.03% glutathione and 0.03%                                          
                  selenomethionine.  See pages 28-29 (“reparative hand and nail formula”), 32-33                           
                  (“protein gel masque”), 34-35 (“sunburn lotion”), 37-38 (“sun gel”), and 38-40                           
                  (“reparative cream”).                                                                                    







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