Ex Parte TAKLE et al - Page 5


                  Appeal No.  2001-1498                                                            Page 5                   
                  Application No.   08/912,378                                                                              
                         Accordingly, we reverse the rejection of claims 9-12 and 14 under 35                               
                  U.S.C. § 102(b) as anticipated by Gibbs.                                                                  
                  THE REJECTION UNDER 35 U.S.C. §§ 102(b)/103:                                                              
                         The examiner maintains his rejection of claim 13 over Gibbs utilizing the                          
                  same evidence set forth in the rejection under 35 U.S.C. § 102(b).  Claim 13,                             
                  however, ultimately depends from claim 9.  Therefore, for the reasons set forth,                          
                  supra, we reverse the rejection of claim 13 under 35 U.S.C. § 102(b) as                                   
                  anticipated by or, in the alternative, under 35 U.S.C. § 103 as obvious over                              
                  Gibbs.                                                                                                    
                  THE REJECTIONS UNDER 35 U.S.C. § 103:                                                                     
                  Claims 1-4:                                                                                               
                         According to the examiner (Answer, page 7-8), Takle, “discloses methods                            
                  of delivery of microparticles bearing the porphyrin heme and external guide                               
                  sequences (EGS) into liver cells”; George, “discloses methods of delivery of                              
                  microparticles bearing the porphyrin heme and external guide sequences (EGS)                              
                  into liver cells”; and Sessler, “discloses delivery of any negatively charged                             
                  substances, including antisense oligonucleotides, with the porphyrin derivative                           
                  turcasin, into cells.”  However, the examiner recognizes (Answer, page 8) that                            
                  “Takle, George and Sessler do not teach methods of delivery of compositions to                            
                  bacterial cells.”  To make up for this deficiency, the examiner relies on Merchat                         
                  to teach “the delivery of porphyrin compounds to bacterial cells.”  Id.                                   
                         In response, appellants argue (Brief, page 9), that the external guide                             
                  sequences of Takle and George are not directly bound to the porphyrin as is                               







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