Ex Parte LENTZ - Page 2


            Appeal No. 2001-2168                                                      
            Application No. 09/083,307                                                

            response against transformed, infected or diseased tissue.                
            Appellant’s invention is useful in the treatment of cancer.               
                 According to appellant’s invention, the patient’s                    
            blood is pumped through a filter having a cutoff of 120,000               
            daltons1 to remove those blood components having molecular                
            weights equal to or less than the filter cutoff and                       
            comprised of immunosuppressive components.  The removal of                
            the immunosuppressive components by the filter is said to                 
            improve the patient’s immune response to the disease or                   
            infection being treated.                                                  
                 A copy of the appealed claims is appended to                         
            appellant’s brief.                                                        
                 The following references are relied upon by the                      
            examiner as evidence of obviousness in support of the                     
            rejections under 35 U.S.C. § 103:                                         
            Lentz              4,708,713            Nov. 24, 1987                    
            Okarma et al.       5,523,096            Jun. 04, 1996                    
            (Okarma)                                                                  
            Wolpe              5,861,483            Jan. 19, 1999                    

                                                                                      
            1 The manner in which the filter is disclosed and claimed in              
            appellant’s application presupposes a predetermined                       
            relationship between the size of the components in the                    
            blood and the molecular weight of those components (e.g.,                 
            the smaller the size, the smaller the molecular weight). We               
            understood that it is customary in the art to define the                  
            size of membrane filters or ultra filters, as they are also               
            called, in terms of the molecular weight of the blood                     
            components passed by the filter.                                          

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