Ex Parte LENTZ - Page 3


            Appeal No. 2001-2168                                                      
            Application No. 09/083,307                                                

            Chen et al., “Soluble TNF-alpha receptors are                             
            constitutively shed and downregulate adhesion molecule                    
            expression in malignant gliomas.” Journal of Neuropathology               
            and Experimental Neurology, vol. 56, no. 5 (May 1997)                     
            pp.541-550                                                                
                 The appealed claims stand rejected under § 103 as                    
            follows:                                                                  
                 1. Claims 1-4, 8, 9, 16, 18-20 and 22 as unpatentable                
            over Lentz;                                                               
                 2. Claim 21 as unpatentable over Lentz in view of                    
            Okarma;                                                                   
                 3. Claim 7 as unpatentable over Lentz in view of Chen;               
            and                                                                       
                 4. Claims 5, 6, 10-15, 17 and 23 as unpatentable over                
            Lentz in view of Wolpe.                                                   
                 Reference is made to the examiner’s answer for details               
            of the foregoing rejections.                                              
                 With regard to the first rejection listed above (i.e.,               
            the rejection based on Lentz alone), we note that claims 1-               
            4, 9 and 18-20 have been grouped together by appellant for                
            determining the issue of patentability (see page 4 of the                 
            main brief).  This group of claims has been identified as                 
            group 12 on page 11 of the main brief.  Under these                       
            circumstances, we are authorized under 37 CFR                             

                                                                                      
            2 On page 4 of the main brief, roman numerals are used to                 

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