Interference No. 104,290
It is our additional finding that LeVeen recognized the
heat-sink problem in his grant request proposal. LX-1146 at 24.
LeVeen stated in the proposal:
All of the tests to date have been ex-vivo,
and needless to say in-vivo testing must be
performed. We recognize the significant heat
sink afforded by flowing blood will alter the
in-vivo results somewhat, but we are optimis
tic that this system has potential of ablat
ing a large enough volume of tissue to be
clinically useful in a large number of
patients.
Thus, it can be seen that LeVeen recognized possible shortcomings
in the tests as previously performed. LeVeen goes on to state in
the potential pitfalls section of the proposal that dramatic
heat-sink effects may result in insufficient heating in vivo.
LX-1146 at 28.
Lastly, as recognized in our discussion of the lack of
any formal protocol for the demonstrations, explorations, or
experiments conducted in June through October of 1993,.the only
evidence that the experiments were regarded as successful are
the non-contemporaneous conclusory statements of success found
in the declarations. The declarations do not establish success
by comparison to any formal oral or written protocol. LeVeen
27
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