Appeal No. 1998-0667 Page 2
Application No. 081280,306
Claims I,2, 6, 18, and 29 are representative of the subject matter on appeal and
read as follows:
1. A method of transferring material into a host cell comprising
providing a pseudocapsid formed from a papovavirus major capsid antigen and
excluding minor capsid antigens, which pseudocapsid has exogenous material
associated therewith; and
treating the host cell with the pseudocapsid so that the material is taken up by
the cell and is biologically functional in that cell.
2. A method as claimed in claim 1 wherein the biological functioning of the
exogenous material in the host cell has a therapeutic effect on a multi-cellular organism
contair~ing tkat cell.
6. A pseudocapsid formed from papovavirus major capsid antigen and excluding
minor capsid antigens, which pseudocapsid has exogenous material associated
therewith; but excluding pseudocapsids associated with exogenous genetic material
and no other exogenous material when the pseudocapsid is formed from only the
mouse polyoma virus major capsid antigen VPI.
18. A method of making a pseudocapsid comprising providing an empty
pseudocapsid formed from papovavirus major capsid antigen and excluding minor
capsid antigens; providing exogenous material; and mixing the empty pseudocapsid
and exogenous material whereby the exogenous material becomes associated with the
empty pseudocapsids; but excluding a method in which exogenous genetic material is
associated with an empty pseudocapsid formed from only the mouse polyoma virus
major capsid antigen, VP1.
29. A pseudocapsid formed from papovavirus major capsid antigen and
excluding minor capsid antigens, which pseudocapsid has exogenous material
associated therewith, wherein the pseudocapsid transfers the exogenous material into
a host cell so that the material is taken up by the cell and is biologically functional in the
cell.
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