Ex Parte HOLMGREN et al - Page 5




              Appeal No. 1999-2634                                                                                         
              Application No. 08/108,606                                                                                   

              Soderlind or Gregory and Myers in further view of Evans 2.   Claim 11 stands rejected                        
              under 35 U.S.C. ' 103 over Evans 1 in view of Svennerholm, and Soderlind or Gregory                          
              and Myers in further view of Evans 3.                                                                        
                     In rejecting claims under 35 U.S.C. ' 103, the examiner bears the initial burden                      
              of presenting a prima facie case of obviousness.  See In re Rijckaert, 9 F.3d 1531,                          
              1532, 28 USPQ2d 1955, 1956 (Fed. Cir. 1993).   A prima facie case of obviousness is                          
              established when the teachings from the prior art itself would appear to have suggested                      
              the claimed subject matter to a person of ordinary skill in the art.  In re Bell, 991 F.2d                   
              781, 783, 26 USPQ2d 1529, 1531 (Fed. Cir. 1993).  An obviousness analysis requires                           
              that the prior art both suggest the claimed subject matter and reveal a reasonable                           
              expectation of success to one reasonably skilled in the art.   In re Vaeck, 947 F.2d 488,                    
              493, 20 USPQ2d 1438, 1442  (Fed. Cir. 1991).    With this as background, we analyze                          
              the prior art applied by the examiner in the rejection of the claims on appeal.                              





              Claim 7                                                                                                      
                     According to the examiner, (Paper No. 16, page 4)                                                     
                            Evans et al teach a method for producing an E. coli bacterial strain                           
                     expressing colonization factor antigens (CFA/1) for use as an oral vaccine                            
                     against enteric infection which has the following steps: (1) growing the E.                           

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