Appeal No. 2001-1436 Page 2
Application No. 08/422,612
(b) a control region capable of being recognized by polymerases
of the yeast cell for expression of said polypeptide in said
yeast cell; and
wherein, after expression, said polypeptide is incorporated into a
cell membrane of said yeast cell and said polypeptide is capable of
binding a ligand of said mammalian receptor.
The examiner relies on the following references:
Dull et al. (Dull) 4,859,609 Aug. 22, 1989
King et al. (King) 5,482,835 Jan. 09, 1996
Dohlman et al. (Dohlman), “A Family of Receptors Coupled to Guanine
Nucleotide Regulatory Proteins,” Biochemistry, Vol. 26, No. 10, pp. 2657-2664
(1987)
Lübbert et al. (Lübbert), “cDNA cloning of a serotonin 5-HT1C receptor by
electrophysiological assays of mRNA-injected Xenopus oocytes,” Proc. Natl.
Acad. Sci. USA, Vol. 84, pp. 4332-4336 (1987)
Dietzel et al. (Dietzel), “The Yeast SCG1 Gene: A GI-like Protein Implicated in
the а- and I-Factor Response Pathway,” Cell, Vol. 50, pp. 1001-1010 (1987)
Kobilka et al. (Kobilka), “Cloning, Sequencing, and Expression of the Gene
Coding for the Human Platelet I2-Adrenergic Receptor,” Science, Vol. 238,
pp. 650-656 (1987)
Claims 16-25, 41, and 44-53 stand rejected under 35 U.S.C. § 112, first
paragraph, as nonenabled.
Claims 16-25, 41, 44-9, 51, and 52 stand rejected under 35 U.S.C.
§ 102(e) as anticipated by King.
Claim 50 stands rejected under 35 U.S.C. § 103 as obvious over King.
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