Ex Parte HIKIDA et al - Page 2


                Appeal No.   2002-1575                                                  Page 2                
                Application No.  08/945,901                                                                   

                                         GROUND OF REJECTION                                                  
                      Claims 4, 5, 8-15, 21, and 24-30 stand rejected under 35 U.S.C. § 102(b)                
                as anticipated by or, in the alternative, under 35 U.S.C. 103 as obvious over                 
                Mita.                                                                                         
                      We reverse.                                                                             
                                                DISCUSSION                                                    
                      Mita teach a method for healing wounds caused by corneal injury, which                  
                includes administering to a patient an effective wound healing amount of                      
                lactoferrin either alone or in admixture with a least one excipient.  Abstract.  Mita         
                disclose (column 1, lines 57-60) that their method is useful for treatment of                 
                various corneal disorders such as corneal injury caused by ulceration,                        
                inflammation or ophthalmological surgery.  In addition, Mita disclose that the                
                concentration of lactoferrin in an eye drop formulation would preferably be 0.01-             
                3.0%.  Column 2, lines 2-5.  However in describing the best mode for carrying                 
                out their invention, Mita disclose the use of a 0.5% (w/v) lactoferrin formulation.           
                Column 2, lines 11-25.                                                                        
                      The examiner finds (Answer, page 4), “[t]he method steps in Mita are                    
                identical to the method steps of the instant invention in that they comprise                  
                administering to the eyes of a patient a pharmaceutically effective amount of                 
                lactoferrin.”  In addition, the examiner finds (Answer, page 5), “as lactoferrin in           
                the method of Mita is used in the same way and at the same amount as in the                   
                instant case, the specific effect of increasing the strength of the wound closure in          
                [sic] inherently present in the referenced method.”  According to the examiner                






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