Ex Parte HIKIDA et al - Page 4


                Appeal No.   2002-1575                                                  Page 4                
                Application No.  08/945,901                                                                   
                King, 801 F.2d 1324, 1326, 231 USPQ 136, 138 (CAFC 1986).  It is, however,                    
                well established that an anticipating reference “must disclose every element of               
                the challenged claim and enable one skilled in the art to make the anticipating               
                subject matter.”  PPG Industries, Inc. v. Guardian Industries Corp., 75 F.3d 1558,            
                1566, 37 USPQ2d 1618, 1624 (Fed. Cir. 1996).  As set forth in Continental Can                 
                Co. USA, Inc. v. Monsanto Co., 948 F.2d 1264, 1269, 20 USPQ2d 1746,                           
                1749-50 (Fed. Cir. 1991) (citations omitted), inherency “may not be established               
                by probabilities or possibilities.  The mere fact that a certain thing  may result            
                from a given set of circumstances is not sufficient.”  Instead, the natural result            
                flowing from the method disclosed in Mita must result in the performance of the               
                questioned function.                                                                          
                      In this regard, appellants point out (Brief, page 7), “[i]t has been reported[1]        
                that a compound which exhibits a corneal wound healing effect by a stimulative                
                effect on the proliferation of corneal keratocytes does not always exhibit a                  
                strength of a wound closure site after healing.”  Therefore, appellants conclude              
                that the stimulative effects on the proliferation of corneal keratocytes [disclosed           
                by Mita, column 1, lines 26-31] and effects on the strength of a wound closure                
                site are not inherently the same.  The examiner does not address this argument.               
                      We remind the examiner that an inherent limitation is one that is                       
                necessarily present; invalidation based on inherency is not established by                    
                “probabilities or possibilities.”  Scaltech, Inc. v. Retec/Tetra, LLC., 178 F.3d              
                1378, 1384, 51 USPQ2d 1055, 1059 (Fed. Cir. 1999).  Instead, it is the                        

                                                                                                              
                1 The Cornea: Transactions of the World Congress on the Cornea III, pp. 15-21 (H. Dwight      
                Cavanagh ed., Raven Press, New York)(1988).                                                   





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